Title Differential potential for envelope glycoprotein - mediated steric shielding of host cell surface proteinsamong

Differential potential for envelope glycoprotein-mediated steric shielding of host cell surface proteins among filoviruses.

The viral envelope glycoprotein (GP) is thought to play important roles in the pathogenesis of filovirus infection. It is known that GP expressed on the cell surface forms a steric shield over host proteins such as major histocompatibility complex class I and integrin β1, which may result in the disorder of cell-to-cell contacts and/or inhibition of the immune response. However, it is not clari...

Steric Shielding of Surface Epitopes and Impaired Immune Recognition Induced by the Ebola Virus Glycoprotein

Many viruses alter expression of proteins on the surface of infected cells including molecules important for immune recognition, such as the major histocompatibility complex (MHC) class I and II molecules. Virus-induced downregulation of surface proteins has been observed to occur by a variety of mechanisms including impaired transcription, blocks to synthesis, and increased turnover. Viral inf...

Suppression of Fas-mediated apoptosis via steric shielding by filovirus glycoproteins.

Apoptotic death of virus-infected cells is generally thought to be a defense mechanism to limit the spread of infectious virions by eliminating virus-producing cells in host animals. On the other hand, several viruses have been shown to have anti-apoptotic mechanisms to facilitate efficient viral replication and transmission. In this study, we found that the filovirus glycoprotein (GP) expresse...

Title Suppression of Fas - mediated apoptosis via steric shielding by filovirus glycoproteins

Modification of Cell Surface Glycoproteins, Macrophage Cytostasis, and Blood-borne Metastatic Properties of the Murine RAW117 Large Cell Lymphoma by Virus Superinfection1

Highly metastatic sublines of the murine RAW117-P large cell lymphonta parental line have been selected sequentially in viro for enhanced blood-borne organ colonization. We found that the subline RAW117H10, selected 10 times for liver colonization, formed more than 200 times as many liver tumor nodules than the RAW117-P line and showed loss of cell surface RNA tumor virus M, 70,000 envelope gly...